Design, formulation, and evaluation of novel sustain release bioadhesive in-situ gelling ocular inserts of ketorolac tromethamine
نویسندگان
چکیده
منابع مشابه
Ofloxacin Ocular Inserts: Design, Formulation and Evaluation
In developing a drug delivery strategy, issues of absorption, distribution, metabolism, and elimination must be considered. The eye presents unique opportunities and challenges when it comes to the delivery of pharmaceuticals. While absorption by this route is bungling, there are few side effects with conventional ocular dosage forms. Hence, ocular inserts were prepared with prolonged release o...
متن کاملOcular pharmacokinetics of 0.45% ketorolac tromethamine
PURPOSE A new carboxymethylcellulose (CMC)-containing ophthalmic formulation of 0.45% ketorolac, pH 6.8 (Acuvail(®)) was recently developed for treatment of inflammation and pain after cataract surgery. This study compared pharmacokinetics of the new formulation with that of a prior formulation, 0.4% ketorolac, pH 7.4 (Acular LS(®)). METHODS Ketorolac formulations were administered bilaterall...
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The eye presents unique opportunities and challenges when it comes to the delivery of Pharmaceuticals. While absorption by this route is bungling, there are few side effects with conventional ocular dosage forms like eye drops and eye suspensions. Several polymeric systems have been used to fabricate ocular inserts for better ocular bioavailability and retention of drug for which gelling system...
متن کاملIn-vitro Release Characterization of Ketorolac Tromethamine Loaded Matrix Tablets
The present investigation highlighted the formulation and release characterization of Ketorolac Tromethamine loaded matrix tablet. Various formulations of tablets were prepared by direct compression method along with Kollidon SR and Hydroxy Propyl Methyl Cellulose (HPMC) as release retardant polymers. Each of the formulated tablets contains 50mg Ketorolac Tromethamine. The evaluation involved p...
متن کاملFormulation and Evaluation of Mouth Dissolving Tablet of Ketorolac Tromethamine for Pain Management by Using Superdisintegrants
s: Mouth dissolving tablet is the fast growing and highly accepted drug delivery system. This study was aimed at development of Ketorolac Tromethamine mouth dissolving tablet, which can disintegrate or dissolve rapidly once placed in the oral cavity. Conventional Ketorolac tromethamine tablet require water to swallow it and have disadvantages like low disintegration rate, low solubility etc.Ket...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutical Investigation
سال: 2014
ISSN: 2230-973X
DOI: 10.4103/2230-973x.143131